Blar i forfatter "Meng, Wei"

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    • Analysis of methylation data with imputation with blocks (MethylBlocks) 

      Meng, Wei; Ray, Mithlesh Kumar; Fenton, Christopher Graham; Anderssen, Endre; Paulssen, Ruth H (Conference object; Konferansebidrag, 2022)
      <p><i>Background -</i> Analysis of methylation data is dependent on two inputs. The total number of reads at any given cytosine site (coverage), and how many of those cytosines are methylated (methylation). Both the large number of sites and low coverage can cause problems in the analysis of methylation data. Likewise finding DMR is computationally and statistically challenging. Here we present a ...

    • Anti-apoptotic genes and non-coding RNAs are potential outcome predictors for ulcerative colitis 

      Meng, Wei; Johnsen, Kay-Martin; Fenton, Christopher Graham; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-18)
      Due to the lack of clinical, immunologic, genetic, and laboratory markers to predict remission in ulcerative colitis (UC) without relapse, there is no clear recommendation regarding withdrawal of therapy. Therefore, this study was to investigate if transcriptional analysis together with Cox survival analysis might be able to reveal molecular markers that are specific for remission duration and ...

    • Methylation-regulated long non-coding RNA expression in ulcerative colitis 

      Fenton, Christopher Graham; Ray, Mithlesh Kumar; Meng, Wei; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)
      Long non-coding RNAs (lncRNAs) have been shown to play a role in the pathogenesis of ulcerative colitis (UC). Although epigenetic processes such as DNA methylation and lncRNA expression are well studied in UC, the importance of the interplay between the two processes has not yet been fully explored. It is, therefore, believed that interactions between environmental factors and epigenetics ...